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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T23861 | CAY10526 | CAY-10526,BTH,CAY 10526 | Prostaglandin Receptor |
CAY10526 (BTH) is a selective mPGES-1 inhibitor that acts as an inhibitor of the NF-κB signaling pathway. | |||
T5727 | CAFESTOL | ERK , NF-κB , COX , PGE Synthase | |
CAFESTOL is a ERK inhibitor for AP-1-targeted activity against PGE2 production and the mRNA expression of cyclooxygenase (COX)-2 in LPS-activated RAW264.7 cells. Cafestol has strong inhibitory activity on PGE2 production... | |||
T5774 | Demethylsuberosin | 7-demethylsuberosin | Prostaglandin Receptor |
7-Demethylsuberosin (7-demethylsuberosin) is a coumarin compound isolated from Angelica gigas Nakai,and has anti-inflammatory activity,and exhibited inhibitory effects on PGE2 production with the IC50 values of 9.42 μM. | |||
T5S1981 | Alpha-Cyperone | (+)-α-Cyperone,α-Cyperone | Others , Endogenous Metabolite |
1. alpha-Cyperone (α-Cyperone) is a promising inhibitor of Hla production by S. aureus and protects lung cells from this bacterium. 2. alpha-Cyperone significantly inhibited PGE2 production by suppressing the LPS-induced... | |||
T3926 | Echinatin | Retrochalcone | Free radical scavengers |
Echinatin (Retrochalcone) disturb the mitochondrial energy transfer reactions and membrane permeability, at a low concentration cause deterioration of respiratory control and oxidative phosphorylation of isolated rat liv... | |||
T2S2335 | Dehydroevodiamine | DHED | Others , NF-κB , COX , PGE Synthase , NO Synthase |
Dehydroevodiamine (DHED), a constituent of Evodia rutaecarpa, has various biological effects such as hypotensive, negative chronotropic, ion channel depressant, inhibition of nitric oxide production and cerebral blood fl... | |||
T5S0045 | Isofraxidin | 6,8-Dimethoxyumbelliferone,Phytodolor | MMP , ERK , p38 MAPK , TLR , COX |
1. Isofraxidin (Phytodolor) protects leukemia cells from radiation-induced apoptosis via ROS/mitochondria pathway in a p53-independent manner. 2. Isofraxidin has a protective effect against LPS-induced ALI, and the prote... | |||
T35610 | 2,5-dimethyl Celecoxib | Apoptosis , Wnt/beta-catenin , Prostaglandin Receptor | |
2,5-dimethyl Celecoxib is a derivative of celecoxib that does not inhibit COX-2 (IC50 = >100 μM).1 It does inhibit microsomal prostaglandin E synthase-1 (mPGES-1) in HeLa cells (IC50 = 15.6 μM) and reduces prostaglandin ... | |||
T6S0735 | Flavokawain B | Flavokavain B,Flavokawin B,2'-Hydroxy-4',6'-Dimethoxychalcone | Apoptosis , Others |
1. Flavokawain B (Flavokavain B) has potent anti-inflammatory activity, can significantly inhibit production of NO and PGE2 in LPS-induced RAW 264.7 cells. 2. Flavokawain B, the hepatotoxic constituent from kava root, in... | |||
T1562 | Rebamipide | Proamipide,OPC12759 | Free radical scavengers , COX , Prostaglandin Receptor |
Rebamipide (OPC12759) is a quinolinone derivative with anti-ulcer and anti-inflammatory activities. Rebamipide induces cyclooxygenase 2 (COX2) synthesis which results in an increase in endogenous prostaglandin synthesis ... | |||
T63104 | INOS/PGE2-IN-1 | ||
iNOS/PGE2-IN-1 is an iNOS/PGE2 inhibitor and a potent anti-inflammatory agent. iNOS/PGE2-IN-1 exhibits an inhibitory effect on LPS-induced NO production and has a low ulcerogenic potential. | |||
T37331 | Pyrrophenone | ||
The group IVA phospholipase A2 (PLA2), known as calcium-dependent cytosolic PLA2 (cPLA2), selectively releases arachidonic acid (AA) from membrane phospholipids, playing a central role in initiating the synthesis of pros... | |||
TN2169 | Saikogenin D | IL Receptor , Calcium Channel , Prostaglandin Receptor | |
Saikogenin D possesses a dual effect: an inhibition of A23187-induced PGE2 production without a direct inhibition of cyclooxygenase activity; and an elevation of [Ca2+]i that is attributed to Ca2+ release from intracellu... | |||
TN4465 | Luvangetin | COX , Prostaglandin Receptor , Antifection | |
Luvangetin may have anti-inflammatory activity, it can inhibit NO and PGE2 production in LPS-stimulated BV2 cells. Luvangetin shows significant protection against pylorus-ligated and aspirin-induced gastric ulcers in rat... | |||
T74781 | UT-11 | ||
UT-11 is a potent brain-permeable inhibitor of microsomal prostaglandin E synthase-1 (mPGES-1), exhibiting IC50 values of 0.10 μM and 2.00 μM for the inhibition of PGE2 production in human (SK-N-AS) and murine (BV2) cell... | |||
TN4879 | Questinol | IL Receptor , TNF , COX , Prostaglandin Receptor | |
Questinol exhibits significant anti-obesity activity. It shows anti-inflammatory effect in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells, it can inhibit the production of pro-inflammatory cytokines, including TNF-α... | |||
T83773 | Prostaglandin E2 Inhibitor 3 | PGE2 Inhibitor 3 | |
Prostaglandin E2 (PGE2) inhibitor 3 is a selective inhibitor targeting microsomal prostaglandin E synthase-1 (mPGES-1; IC50 = 0.2 µM), demonstrating greater selectivity for mPGES-1 over COX-1, COX-2, 5-lipoxygenase (5-LO... | |||
T22172 | YS-121 | ||
YS121 is a dual inhibitor of microsomal prostaglandin E2 synthase-1 ( mPGES-1; IC 50 =3.4 μM) and 5-lipoxygenase ( 5-LOX; IC 50 =6.5 μM). YS121 dose-dependently reduces the production of PGE2 with EC 50 =12 μM in IL-1β-s... | |||
T63919 | IKKβ-IN-1 | ||
IKKβ-IN-1 is a potent, orally active inhibitor of IkappaB (IKK-β) (IC50: 0.20 μM). IKKβ-IN-1 reduces the inhibition of PGE2 and TNF-α production in murine macrophages. IKKβ-IN-1 protects mice from infection shock-induced... | |||
T70718 | CR-6086 | ||
CR6086 is a novel, potent EP4 antagonist showing favourable immunomodulatory properties, striking DMARD effects in rodents, and anti-inflammatory activity targeted to immune-mediated inflammatory diseases and distinct fr... |